Each player drafts Old Testament prophets, then match each prophets' prophecies about the coming Christ with the fulfillment in the New Testament. Prophets are afflicted with weakness, discouragement & wanderlust or attacked by evil forces. Defend your prophets by surrounding them with loyal friends (other biblical characters), sending guardian angels, or the occasional divine intervention. It's a race for inspiration with the wisdom to not let one's guard down.
From designers website (http://www.unitygame.com)
"Prophecy is a very easy game to play. On each turn, you just draw a card and then play any card in your hand (that is playable), or you ask an opponent for a card. It is kind of an enhanced Go Fish. However, determining which is the best card to play is not always as straightforward as it seems."